NMN神药还需要5年?

2020-08-16

  作为维生素衍生物NMN是种天然物质,日本2015年就已经开始卖了,好多用户也已经吃了三年了,市面上也有很多NMN在销售。为何报道说要5年后才能上市呢,这是什么原因呢?

 

 

       其实这有一定的误解!市场上销售的NMN是属于Dietary Supplement(食物补充剂),是食品标准;Dr. David Sinclair和DR.Lindsay Wu所说的五年后上市的NMN是抗衰老药物,是药物标准!

 

 

       其实这和二甲双胍类似,FDA是不承认衰老是一种疾病的,神药二甲双胍1957年已经面市,但是直到2015年FDA才批准了二甲双胍作为抗衰老药物的临床。因为临床是要经过1/2/3期的,所以虽然作为食物补充剂的NMN已经面市,但是作为抗衰老药物的NMN也许要经过5年。

       有些人认为作为药物的NMN面市后,价格会大幅下降,这又存在一定误解:如果NMN作为抗衰老处方药的话,就意味着药企需要批文而购买必须有医生的处方,那么消费者将为药企的垄断支付更高的价格。这和当年药企联合起来想把维C处理成处方药,从而哄抬维C价格一样。
       关于NMN一类物质的临床早已有不错的结果:
       2018年4月:科罗拉多大学博尔德分校的Seals针对24名从55到79岁的测试者证实服用NMN系列物的13名高血压患者收缩压下降10%。
       2017年10月:Nature公布的一个120人的双盲实验,证实了这类物质的安全性。

 

 

“不老神药”=一杯咖啡的价格?

       作为NAD+最有效的补充剂,NMN的主要的在于成本太高。按照植物中的含量,补充100mg的NMN,要吃掉上百千克的水果,这不现实。

 

食物中NMN含量

 

       排除一些纯度不够以及挂羊头卖狗肉的NMN,将市面上广受认可的NMN价格进行比较。实验室级别的NMN比黄金还贵,日本发酵法的NMN次之,酶法的NMN最具竞争力。Herbalmax公司酶法工艺已经将NMN售价降低了五分之一,而香港中文大学的王骏教授全产业链的酶法工艺更是让NMN量产,成本断崖式下降。

 

NMN价格比较

数据来源:淘宝、京东、亚马逊、NMN中国

 

       王骏教授凭借其先进的酶法技术实力,和走在NMN抗衰老研究的哈佛医学院的David Sinclair教授和新南威尔士的Lindsay Wu教授进行了深度合作。

 

 往前看90年多年,人类首次发现维C的惊喜心情和现在发现NMN的惊喜心情颇为类似: 具有一系列神奇功能,且价格较贵! 但现在维C 不到2元就可以买到,NMN也会随着规模的扩大降低成本!追求长生不老是人类一直以来的梦想,能否到150岁还需要探究,但延年重要益寿也同样重要,相信NMN会让人类征服衰老的进程更进一步。

 

参考文献

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2 NAD+ and sirtuins in aging and disease (Imai, 2014)

3 Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (Gomes, Sinclair,2013)

4 un Li, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn, David A. Sinclair. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science 355:1312,(2017)

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7 Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice (Uddin, 2016)

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11 Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease (Yao, 2017)

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13 Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and repercussion

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17 Samuel W.French. Chronic alcohol binging injures the liver and other organs by reducing NAD⁺ levels required for sirtuin's deacetylase activity. Experimental and Molecular Pathology 100:303-306(2016)

18  NAMPT-mediated NAD+ biosynthesis is essential for vision in mice (lin, 2016)

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来源:基因港